In large cities that have air pollution problems the number of emergency department visits for asthma episodes goes up when the air quality is very poor.

What is the BEST way to paraphrase the sentence?

Asthma occurrences are not as frequent in the country.

Large cities often have poor air quality.

Asthma episodes are more frequent in large cities, especially on days of poor air quality.

Several cities with large populations have many asthma-related health problems.

The frequency of asthma episodes increases in large cities with poor air quality.