Can the EGF diffuse through the cell membrane?

Yes, the epidermal growth factor (EGF) can diffuse through the cell membrane. EGF is a small protein molecule, and small molecules like proteins can passively diffuse through the cell membrane if they are non-polar or have regions that are non-polar. However, the diffusion of EGF can also be regulated by specific receptors on the cell membrane that facilitate its transport into the cell.