Frank bought roses at the wholesale flower shop. If each dozen costs him $3.50, what should the selling price be if he wants to make an 80% profit?

Frank bought the roses at $3.50 per dozen.

To make an 80% profit, he needs to sell them for $3.50 + ($3.50 * 80/100) = $3.50 + $2.80 = $<<3.5+2.8=6.30>>6.30 per dozen. Answer: \boxed{6.30}.