Macrophages is affected by HIV?
Yes, macrophages are one of the important immune cells that are affected by HIV (Human Immunodeficiency Virus) infection. HIV primarily targets CD4+ T-cells and macrophages, both of which are major components of the immune system.
Macrophages are responsible for phagocytosis (engulfing and destroying pathogens) and other immune functions. When HIV infects macrophages, it replicates within their cytoplasm but does not cause immediate cell death. This allows the virus to spread to other cells and establish a persistent infection.
HIV infection in macrophages can lead to chronic inflammation, impaired immune response, and increased susceptibility to secondary infections. It also contributes to the spread of the virus throughout the body and the progression of HIV to AIDS (Acquired Immunodeficiency Syndrome).