Describe briefly about type 1 vs type 2 inflammation
Type 1 inflammation is characterized by an immediate, acute immune response against pathogens or tissue damage. It is typically short-lived, resolving once the infection or injury is healed. Type 1 inflammation involves the activation of immune cells, such as neutrophils, natural killer (NK) cells, and macrophages, which release pro-inflammatory cytokines to eliminate the threat and promote tissue repair.
On the other hand, type 2 inflammation is a chronic, ongoing immune response that occurs in conditions like allergies, autoimmune diseases, and metabolic disorders. It is characterized by an overactive immune response, involving immune cells like eosinophils, T-helper 2 (Th2) cells, and mast cells, which release cytokines like interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13). Type 2 inflammation leads to tissue damage and fibrosis and is associated with symptoms like allergies, asthma, and chronic inflammatory diseases.
In summary, type 1 inflammation is an acute response to infection or injury, while type 2 inflammation is a chronic immune response associated with negative health outcomes.