Which of the following was not a challenge experience by the first settlers in South Carolina

The option not listed as a challenge experienced by the first settlers in South Carolina is:

D. Hostile Native American tribes: The first settlers in South Carolina did indeed face challenges from hostile Native American tribes, including conflicts and attacks.

To determine which of the following was not a challenge experienced by the first settlers in South Carolina, we need to know the options you are referring to. Could you please provide the list of options?

To identify which of the following challenges was not experienced by the first settlers in South Carolina, we would need to have a list of challenges to choose from. Please provide the list of challenges.