A cell contains DNA damage that causes it to undergo apoptosis before reaching mitosis. This cell had twice the amount of DNA for a cell of this type. During which checkpoint did this cell trigger apoptosis?(1 point)
Responses
G1 Checkpoint
cap g sub 1 Checkpoint
G2 Checkpoint
cap g sub 2 Checkpoint
M Checkpoint
cap m Checkpoint
No checkpoint meets these criteria.
The correct answer is G2 Checkpoint.
The cell triggered apoptosis during the G2 checkpoint.
To determine during which checkpoint this cell triggered apoptosis, we need to understand the cell cycle and the checkpoints involved.
The cell cycle consists of four main phases: G1 (Gap 1), S (Synthesis), G2 (Gap 2), and M (Mitosis). The checkpoints are specific points in the cell cycle where the progression of the cell is monitored for DNA integrity, chromosomal abnormalities, and other important factors.
In this scenario, the cell had twice the amount of DNA for a cell of this type. This condition indicates DNA damage, which can lead to cell cycle arrest or apoptosis, a programmed cell death mechanism.
The G1 checkpoint is responsible for monitoring DNA integrity and external signals before the cell enters the S phase. The G2 checkpoint monitors DNA damage and ensures that DNA replication has occurred accurately before the cell enters the M phase. The M checkpoint ensures accurate chromosome alignment and attachment to the spindle fibers before the cell proceeds with cytokinesis.
Since the cell with DNA damage triggered apoptosis, it suggests that the DNA damage was identified at a checkpoint, leading to an apoptotic response. Given the information provided, we can infer that the G1 checkpoint did not trigger apoptosis since the cell had progressed past this checkpoint. Similarly, the G2 and M checkpoints also did not trigger apoptosis as the cell was unable to complete DNA replication or reach mitosis.
Therefore, based on the given options, no checkpoint meets the criteria of triggering apoptosis in this scenario.