Which statement is correct about rough ER and smooth ER?

Both statements are correct about rough ER and smooth ER:

1. Rough ER is involved in protein synthesis and has ribosomes attached to its surface, whereas smooth ER is primarily involved in lipid metabolism and lacks ribosomes.
2. Rough ER is responsible for the production of proteins that are destined for secretion or for insertion into the plasma membrane, while smooth ER is involved in the synthesis of lipids, detoxification of drugs and toxins, and calcium ion storage.

The correct statement about rough endoplasmic reticulum (ER) and smooth endoplasmic reticulum (ER) is that the rough ER is involved in protein synthesis and modification, while the smooth ER is involved in lipid metabolism, detoxification, and calcium storage.