Stress induced release of ACTH from the pituitary gland is

has no affect on the immune stem
causes release of cortisol from the adrenal gland which suppresses the immune system
leads to feser
increases the immune response
activates all the non-specific defense systems

causes release of cortisol from the adrenal gland which suppresses the immune system.

The stress-induced release of ACTH (adrenocorticotropic hormone) from the pituitary gland can have several effects on the immune system. One of the main effects is the subsequent release of cortisol from the adrenal gland. Cortisol, also known as the stress hormone, has immunosuppressive properties, which means that it suppresses or dampens the immune system. Thus, the correct statement is "causes release of cortisol from the adrenal gland which suppresses the immune system."