Simplify.

negative 3xy4 times negative 4
A. negative 81x to the fourth y to the sixteenth
B. negative 81 over x4y16
C. negative 1 over 81x4y16
D. fraction

A. negative 12xy4

To simplify -3xy^4 times -4, we can multiply the coefficients (-3 and -4) and combine the variables (x and y).

Multiplying the coefficients: -3 times -4 equals 12.

Combining the variables: The x term does not have an equivalent term to combine with, so it stays as x. The y term has an exponent of 4 and there is no other y term to combine with. Therefore, it stays as y^4.

Putting it all together, the simplified expression is 12xy^4.

So, the answer is not provided in the options given.