A: -12

B: 12

C: 20

D: -20
I picked -20 but I'm not sure if it's right

What do you mean "you picked" -20 ????

We don't "pick" answers in math ! We perform the proper steps to get the correct result

-4 + 16
= 16 - 4
= ....

In a game you are up 16, then you lose 4.
What have you got ?