so you have this chemical you tested on mice and rats now you are going to test it on humans to how much degree can you test on humans? what can you measure ex) mass/body weight?

I can't make sense of the question. "to see how much degree?"

How safe is it to test in on humans? What do you need to measure? so that you can test it on humans?

body weight

pH blood
serum levels
lipids
blood sugar(fasting & A1C)
electrolytes
cardiology test(treadmill, CT scan)\
MRI scans of some organs
etc

When testing a chemical on humans, it is important to prioritize the safety and ethical considerations of the participants. Human testing typically occurs in several stages, known as clinical trials, which progressively evaluate the effects and safety of the chemical. Here's a general overview:

Phase 1: This phase involves a small number of healthy volunteers and focuses on assessing the safety, dosage range, and potential side effects of the chemical. Researchers may measure parameters like body weight, vital signs, blood tests, and organ function to determine how the substance affects humans.

Phase 2: In this phase, a larger group of people who have the specific condition or disease being targeted by the chemical is involved. Researchers aim to evaluate the chemical's effectiveness and further assess its safety. Measurements similar to those in Phase 1 are taken, along with specific disease-related assessments.

Phase 3: This stage assesses the chemical's effectiveness and compares it to existing treatment methods or placebos. A larger and more diverse group of participants is involved. Efficacy, safety, dosage adjustments, and potential interactions with other drugs are closely monitored.

Phase 4: After the chemical receives approval, Phase 4 trials continue to monitor its safety and effectiveness in a larger population over an extended period. Researchers might measure various factors specific to the chemical or underlying conditions, along with long-term effects.

Throughout all phases, informed consent and ethical standards are crucial. The specific measurements taken depend on the goals of the study, the chemical being tested, and the condition it is meant to address. It's important to consult with researchers and medical professionals conducting the trial to understand the measurements and assessments being used in a particular study.