A university student wants to perform an experiment using mice as test subjects. The procedure would require the mice to be injected with a specific bacterial infection and then treated with an antibiotic. Their response to the treatment would be observed and recorded. Provide two questions that an ethics review board would raise regarding the proposed work. For each question, explain why it is important that the question be answered prior to granting permission for the experiment.
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When reviewing an experiment that involves animals, an ethics review board considers factors such as animal welfare, potential harm, and scientific justification. Here are two questions an ethics review board may raise regarding the proposed work and their significance:
1. Does the experiment comply with animal welfare regulations and standards?
It is important to verify that the experiment follows established guidelines and regulations for the humane treatment of animals. This includes ensuring that the mice receive appropriate care, housing, and handling. Addressing this question is crucial because it helps assess the potential harm or distress that the mice may experience during the experiment.
2. Is the proposed experiment scientifically valid and necessary?
It is vital to evaluate the scientific validity and necessity of the experiment. This involves considering whether the experiment addresses a significant scientific question or contributes to valuable knowledge in the chosen field. It is important to verify that the methods proposed are appropriate and that the expected outcomes justify the use of animals in the experiment. Answering this question ensures that the potential harm or discomfort inflicted on the mice is justified by the scientific value of the experiment.