Negative allosteric effectors in the citric acicd cycle.
Theres four:
I have NADH and ATP
What are the other two please help
To identify the other negative allosteric effectors in the citric acid cycle, we can refer to the regulatory enzymes in the cycle. The citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid (TCA) cycle, is a series of enzymatic reactions that occur in the mitochondria and play a crucial role in cellular respiration.
The four negative allosteric effectors in the citric acid cycle are:
1. NADH (nicotinamide adenine dinucleotide, reduced form): NADH acts as a negative allosteric effector for the enzyme isocitrate dehydrogenase. When the concentration of NADH is high, it inhibits the activity of isocitrate dehydrogenase, slowing down the citric acid cycle.
2. ATP (adenosine triphosphate): ATP acts as a negative allosteric effector for two enzymes in the citric acid cycle: isocitrate dehydrogenase and α-ketoglutarate dehydrogenase. High levels of ATP inhibit these enzymes, thereby regulating the rate of the citric acid cycle.
The other two negative allosteric effectors in the citric acid cycle are:
3. Succinyl-CoA: Succinyl-CoA acts as a negative allosteric effector for the enzyme α-ketoglutarate dehydrogenase. High levels of succinyl-CoA inhibit this enzyme, thereby controlling the rate of the cycle.
4. Citrate: Citrate itself acts as a negative allosteric effector of citrate synthase, the enzyme that catalyzes the first step of the citric acid cycle. When the concentration of citrate is high, it inhibits citrate synthase, slowing down the cycle.
Overall, these negative allosteric effectors help regulate the citric acid cycle by responding to the energy needs of the cell and ensuring the balance of intermediates and ATP production.