(b) Is this pedigree consistent with autosomal dominant inheritance?
Yes
No
If you chose "yes", answer questions (i) and (ii) and leave parts (iii) and (iv) blank. If you chose "no", leave parts (i) and (ii) blank and answer questions (iii) and (iv).
i) If you chose "yes" above. Drag and drop in the appropriate genotype from the options below to indicate the genotypes of all the individuals in the pedigree. You may use each of the labels below once, more than once, or not at all. Note that the upper case letter indicates the allele with the dominant phenotype.
A_AaaaAA
unanswered
ii) If you chose "yes" above. If Individuals 5 and 6 have another child, what is the probability that the child will be affected by the disease? Please give a number between 0.0 and 1.0. Use as many significant digits as you need.
unanswered
iii) If you chose "no" above. Which set or sets of individuals are inconsistent with autosomal dominant inheritance? Choose all that apply from the list below:
Individuals 1, 2, 3, and 5
Individuals 3, 4, 7, and 8
Individuals 5, 6, 9, and 10
Individuals 10, 11, 12, and 13
iv) If you chose "no" above. Can you change one individual from unaffected to affected and make this pedigree consistent with autosomal dominant inheritance? If so, give the number of that individual. If it is not possible, enter 0.
unanswered
Numbered individuals?
No. iii) If you chose "no" above. Which set or sets of individuals is inconsistent with autosomal dominant inheritance? Individuals 5, 6, 9, 10, and 11
iv) If you chose "no" above. Can you change one individual from unaffected to affected and make this pedigree consistent with autosomal dominant inheritance? 6
(iii) If you chose "no" above, the set of individuals inconsistent with autosomal dominant inheritance is:
- Individuals 5, 6, 9, and 10
(iv) If you chose "no" above, it is not possible to change one individual from unaffected to affected and make this pedigree consistent with autosomal dominant inheritance. So the answer is 0.
To determine if the pedigree is consistent with autosomal dominant inheritance, we need to examine the genotypes and patterns of inheritance in the family.
(i) If you chose "yes" above, you need to drag and drop the appropriate genotype from the given options to indicate the genotypes of all the individuals in the pedigree. The options are:
A_AaaaAA
Please drag and drop the appropriate genotypes for each individual.
(ii) If you chose "yes" above, you need to determine the probability that a child of Individuals 5 and 6 will be affected by the disease. Please provide a number between 0.0 and 1.0, using as many significant digits as necessary.
(iii) If you chose "no" above, you need to identify which set or sets of individuals are inconsistent with autosomal dominant inheritance. Choose all that apply from the provided list of individuals.
(iv) If you chose "no" above, you need to determine if it is possible to change one individual from unaffected to affected and make the pedigree consistent with autosomal dominant inheritance. If it is possible, provide the number of that individual. If it is not possible, enter 0.
Please provide your answers for (i), (ii), (iii), and (iv) accordingly.