why do we take 85ml of hcl for 1lit solvent according to I.P. while it is 43.02ml when it is calculated
The discrepancy you mentioned in the amount of hydrochloric acid (HCl) to be taken according to the Indian Pharmacopoeia (I.P.) and the calculated value may arise due to various factors. Let's break down the possible reasons:
1. Standardization: In the case of chemicals used in laboratories or pharmaceutical preparations, it is common practice to standardize the concentration or strength of substances. The I.P. may provide specific guidelines or standards for the concentration or strength of HCl, which could differ from the concentration used in your calculation. This could lead to differences in the required volume.
2. Specific Purpose: The intended purpose or use of the solvent may require a specific concentration of HCl to be added. The I.P. may prescribe a higher volume of HCl to achieve the desired concentration for the given application. Alternatively, the calculated value you obtained might be for a different purpose or concentration requirement.
3. Safety Considerations: The I.P. guidelines might also consider safety factors or precautions when determining the volume of HCl to be used. Higher volumes could be recommended to prevent dilutional errors or to account for potential losses during handling or transfer.
To resolve this discrepancy, it would be best to refer to the specific I.P. guidelines and compare them with the purpose and concentration you are aiming to achieve with HCl. Additionally, double-check your calculations to ensure accuracy in determining the appropriate volume. If you still have concerns or doubts, it is advisable to seek guidance from a qualified professional or consult relevant literature.