Under what circumstances can a very small treatment effect still be significant?

a, if the sample size (n) is very large
b, if the sample standard deviation is very large
c, if the standard error of M is very large
d, all of the other factors are likely to produce a significant result?

Under certain circumstances, a very small treatment effect can still be significant. The factors that can contribute to this include:

a) If the sample size (n) is very large: A larger sample size increases statistical power, making it easier to detect even small treatment effects.

b) If the sample standard deviation is very large: A larger standard deviation indicates greater variability in the data. This can increase the likelihood of finding a significant treatment effect, even if it is small.

c) If the standard error of M is very large: The standard error of the mean (M) is a measure of the precision of the estimate. A larger standard error can make small treatment effects statistically significant.

d) All of the other factors are likely to produce a significant result: In some cases, a small treatment effect can still be significant if multiple factors, such as a large sample size, large standard deviation, or large standard error of M, are present at the same time.

It is important to note that the significance of a treatment effect depends on the specific context and the desired level of significance (e.g., p-value threshold).

To determine the circumstances under which a very small treatment effect can still be significant, we need to understand the factors that influence statistical significance. Statistical significance is typically determined using hypothesis testing, specifically comparing the treatment effect to the variability observed in the data.

The significance of a treatment effect is often evaluated using a p-value, which measures the strength of evidence against the null hypothesis (the assumption that there is no treatment effect). A small p-value suggests that the observed treatment effect is unlikely to occur by chance alone.

Now, considering the given options:

a) If the sample size (n) is very large: In hypothesis testing, larger sample sizes tend to increase the statistical power, making it easier to detect small treatment effects. With a large sample size, even very small treatment effects can yield significant results.

b) If the sample standard deviation is very large: Large variability in the data reduces the precision and increases the uncertainty of the estimate. Consequently, it can be easier for even small treatment effects to stand out against this greater background variability, making them statistically significant.

c) If the standard error of M is very large: The standard error of the mean (M) reflects the precision of the treatment effect estimate. When the standard error is large, the estimate becomes less precise, allowing even small treatment effects to be potentially significant.

Therefore, d) all of the other factors (large sample size, large sample standard deviation, or large standard error of M) can be influential in producing a statistically significant result despite a very small treatment effect.

d. all of the other factors are likely to produce a significant result