Which of the following is not like the other?

Cortes, Pizarro, Champlain, and Ponce de Leon

Champlain was French. The others were Spanish.

To determine which one of the given options is not like the others, we need to analyze the similarities and differences among the individuals listed: Cortes, Pizarro, Champlain, and Ponce de Leon.

1. Cortes: Hernan Cortes was a Spanish conquistador who played a significant role in the conquest of the Aztec Empire in modern-day Mexico.
2. Pizarro: Francisco Pizarro was a Spanish conquistador known for conquering the Inca Empire in modern-day Peru.
3. Champlain: Samuel de Champlain was a French explorer and navigator who established the city of Quebec and played a vital role in the colonization of New France, which later became part of Canada.
4. Ponce de Leon: Juan Ponce de Leon was a Spanish explorer who is best known for his expeditions to Florida and his search for the "Fountain of Youth."

Based on the above information, the answer to the question is Champlain. This is because the other three options, Cortes, Pizarro, and Ponce de Leon, were Spanish conquistadors involved in the exploration and colonization of the Americas, whereas Champlain was a French explorer and navigator involved in the colonization of New France.

To arrive at this conclusion, one needs to have knowledge of the historical background of each individual, their nationalities, and their roles in exploration and colonization.