If trypsin and chymotrypsin become activated within the pancreas and then are released in their active forms into the bloodstream, why would this represent a potentially life-threatening situation?
This situation represents a potentially life-threatening situation because trypsin and chymotrypsin are digestive enzymes that are normally secreted in an inactive form in the pancreas. Activation of these enzymes within the pancreas can lead to an excessive release of active trypsin and chymotrypsin into the bloodstream. Here's why it could be dangerous:
1. Digestive system disruption: Once activated, trypsin and chymotrypsin start breaking down proteins into smaller fragments. In the bloodstream, these enzymes can lead to uncontrolled protein digestion, which can damage blood vessel walls, tissues, and organs.
2. Pancreatic self-digestion: If trypsin and chymotrypsin become prematurely activated within the pancreas, they can start digesting the pancreas itself. This can cause inflammation, tissue damage, and pancreatitis, a serious condition that can lead to organ failure.
3. Systemic effects: The release of excessive active trypsin and chymotrypsin into the bloodstream can result in systemic inflammation, which can lead to multiple organ dysfunction syndrome (MODS). MODS is a life-threatening condition where the dysfunction of one organ triggers a domino effect on other organs, potentially causing organ failure.
Overall, the release of these enzymes in their active forms into the bloodstream disrupts normal physiological processes, leading to severe consequences for various organs and systems in the body.