le duele la cabeza - my head hurts

or is it I hace a headache

me siento cansado - I am tired???

Check the "le" because no way is it MY head. My head hurts/I have a headache = ME duele la cabeza.

Check what I wrote before: LE duele la cabeza is either HER/HIS/YOUR-singular/formal head aches.

Me siento cansado = YES, I am tired.

Sra