David Hassenzahl discusses the relative risks of eating peanut butter contaminated with aflatoxin and apple juice contaminated with UDMH, a degradation product of Alar, in the Power Point presentation in the Week Five, Module 5 Conference. The following Table shows his input data.
Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
a. Calculate the daily cancer risk for a child who weighs 20 kg and who eats an average amount of peanut butter
b. Do the same for a 20 kg child who drinks an average amount of apple juice.
NOTE: Daily cancer risk = Intake x Concentration x Potency / Body Weight
c. Calculate the maximum daily cancer risks for peanut butter and apple juice based on the 95th percentiles.
human risk assessment - drwls, Sunday, November 4, 2007 at 6:35am
No Table is shown.
human risk assessment - Thano, Sunday, November 4, 2007 at 6:45am
Variable Units Average 5th %ile 95th %ile Distribution
Peanut butter intake g/day 11.38 2.00 31.86 Lognormal
Apple juice intake g/day 136.84 16.02 430.02 Lognormal
Aflatoxin concentration ug/kg 2.82 1.00 6.5 Lognormal
UDMH concentration ug/kg 13.75 0.5 42.00 Lognormal
Aflatoxin potency kg-day/mg 17.5 4.02 28.33 Normal
UDMH potency kg-day/mg 0.49 0.00 0.85 Normal
To calculate the daily cancer risk, we need to use the formula:
Daily cancer risk = Intake x Concentration x Potency / Body Weight
a. Let's calculate the daily cancer risk for a child who weighs 20 kg and eats an average amount of peanut butter.
- The average peanut butter intake is given as 11.38 g/day.
- The average aflatoxin concentration is given as 2.82 ug/kg.
- The average aflatoxin potency is given as 17.5 kg-day/mg.
Substituting these values into the formula:
Daily cancer risk = 11.38 g/day x 2.82 ug/kg x 17.5 kg-day/mg / 20 kg
b. Now, let's calculate the daily cancer risk for a 20 kg child who drinks an average amount of apple juice.
- The average apple juice intake is given as 136.84 g/day.
- The average UDMH concentration is given as 13.75 ug/kg.
- The average UDMH potency is given as 0.49 kg-day/mg.
Substituting these values into the formula:
Daily cancer risk = 136.84 g/day x 13.75 ug/kg x 0.49 kg-day/mg / 20 kg
c. To calculate the maximum daily cancer risks for peanut butter and apple juice based on the 95th percentiles:
- For peanut butter:
- Intake at 95th percentile: 31.86 g/day
- Aflatoxin concentration at 95th percentile: 6.5 ug/kg
Calculate the daily cancer risk using the formula as before.
- For apple juice:
- Intake at 95th percentile: 430.02 g/day
- UDMH concentration at 95th percentile: 42.00 ug/kg
Calculate the daily cancer risk using the formula as before.
Please note that the Table mentioned in the initial question is not provided, so the exact values for the calculations couldn't be shown. You'll need to refer to the actual table mentioned in the Week Five Module 5 Conference to obtain the specific values for the calculations.