Gah. Struggling over this for the past 20 minutes...

Find the slope of the line tangent to the curve y=1/x at the point (2,0.5).

This is just a simple application of the power rule:

y(x) = 1/x = x^-1
y'(x) = (-1)x^-2 = -1/x^2

So, y'(2) = -1/4