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using the hasselbach-Handerson equation calculate the fraction of asprin Pka is 5.6 and PH is 8.6?

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  1. If you need more information on the equation, try some of the following links:

    http://search.yahoo.com/search?fr=mcafee&p=hasselbach-Handerson+equation

    For the calculation itself, you might find something useful in some of the following:

    http://search.yahoo.com/search?fr=mcafee&p=calculate+the+fraction+of+asprin+Pka+is+5.6+and+PH+is+8.6%3F

    Sra

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  2. Do you want the fraction [A-]/[HA] dissociated?

    [Your value for the pKa for aspirin is low from memory =about 3.5??]

    From the H-H equation

    pH=pKa+log([A-]/[HA])

    8.6=5.6 + log([A-]/[HA])

    3.0=log([A-]/[HA])

    so

    10^+3 = [A-]/[HA]

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