1. See the X on the map?

2. Do you se the X on the map?
(Does #1 mean #2?)

3. Is anyone in your family a caregiver to sick people?
(Is this a correct sentence?)

4. The girl is well grounded in French.
(Is this correct? Would you paraphrase this one with another expression?)

5.The unfortunate accident poisoned the whold holidays.

6. The unfortunate accident spoiled the whold holidays.

7. The unfortunate accident ruined the whole hoidays.

(Are the three the same and grammatical?)

1 and 2 have the same meaning, yes.

3. Is anyone in your family a caregiver to sick people?
(Is this a correct sentence?) Yes, it's fine.

4. The girl is well grounded in French.
(Is this correct? Would you paraphrase this one with another expression?)
The girl is fluent in French.
The girl knows French very well.


5.The unfortunate accident poisoned the whole holiday.

6. The unfortunate accident spoiled the whole holiday.

7. The unfortunate accident ruined the whole holiday.

And, yes, all mean the same thing.