# Loop of Henle

What would happen to the concentration gradient in the tissues in the thick ascending limb loop of Henle if you used loop diuretics for too long?

I know that if you use them K+ isnt being recycles and therefore theres no electropositive gradient being created and therefore no reabsorption of cations like sodium, potassium, magnesium and calcium. But I don't know what happens to the concentration gradient for prolonged used. Would you just get an accumulation of the cations?

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