1. He is from USA.

2. He is from the USA.

(Are both OK? Do we have to use 'the' before USA all the time?)

#2 yes. "the United States"

Sra

Both sentences are grammatically correct, but they have slightly different meanings.

In sentence 1, "He is from USA," the word "USA" is used as a proper noun without the definite article "the." This usage is not typically seen in formal writing, but it may be used in informal or conversational contexts.

In sentence 2, "He is from the USA," the definite article "the" is used before "USA." This is more commonly used and appropriate in formal writing and standard English. When referring to a particular country, it is common to use the definite article "the."

So, in most cases, it is more appropriate to use "the" before "USA" when referring to the country. However, the use of "the" may vary depending on the context and style of writing.