When infected with certain bacteria or viruses our bodies produces a fever. Fevers occur when the hypthalamus changes its temperature set point. Signaling of the hypothalamus could be direct (from infectious agent itself) or indirect (from the immune sytem). Which of these would enable the hypothalamus to respond to the greatest variety of infectious agents? Is there any disadavantage to such a signaling system?

obviously, reactions from the immune system. Why? THink about it. And what would be the disadvantage.