A cell cycle is exposed to intensive UV irradiation that results in damage to the cells DNA. Shortly after UV exposure, the cell receives signals telling it to undergo cell division. What are the most likely next events to occur in the cell?
A- The cell will undergo mitotic cell division, however, the damaged DNA will not be replicated and therefore transmitted through to the daughter cells
B- The cell will proceed though G1; at the G1 to S phase checkpoint, p53 will halt the cell cycle in response to the DNA damage.
C- Repair of the DNA damage will occur prior to the cell initiating G1 of the cell cycle.
D- The cell will proceed through all stages of the cell cycle and undergo one round of mitotic division.
E- The cell will proceed through G1, S, and G2; at the G2 checkpoint, the cell cycle will be halted by p53 and DNA repair will take place.
A and D seem unreasonable, but my book has almost no information on this material and I have not been able to find something to help me online.
Please Help
Thanks in advance
IDK HELP ME!!!!!!!!1
To determine the most likely next events to occur in the cell after UV irradiation, let's analyze the options:
A - The cell will undergo mitotic cell division, but the damaged DNA will not be replicated and transmitted to the daughter cells. This option suggests that the damaged DNA will not be repaired before cell division, which would lead to the transmission of the damaged DNA. This scenario is usually avoided by cellular mechanisms that halt the cell cycle to allow DNA repair.
B - The cell will proceed through G1, and at the G1 to S phase checkpoint, p53 will halt the cell cycle in response to the DNA damage. The p53 protein is a key regulator that responds to DNA damage. In the case of UV-induced damage, p53 is activated to pause the cell cycle and allow for DNA repair before proceeding further.
C - Repair of the DNA damage will occur prior to the cell initiating G1 of the cell cycle. This option suggests that DNA repair will take place before the cell enters the first phase of the cell cycle. It aligns with the concept of preserving a healthy genome and preventing the transmission of damaged DNA to daughter cells.
D - The cell will proceed through all stages of the cell cycle and undergo one round of mitotic division. This option implies that the cell will continue the cell cycle without any interruption for DNA repair. In the case of extensive DNA damage, it is unlikely that the cell would proceed without activating DNA repair mechanisms first.
E - The cell will proceed through G1, S, and G2; at the G2 checkpoint, the cell cycle will be halted by p53, and DNA repair will take place. This option suggests that the cell will undergo DNA repair during the G2 phase of the cell cycle rather than earlier. The idea is that the cell repairs DNA damage before entering the mitotic phase.
Based on the information you provided, options C and E are the most reasonable predictions. These options both propose DNA repair occurring before the cell progresses further into the cell cycle. However, without further data or context, it is difficult to determine the exact events following UV irradiation. It might be helpful to consult additional resources or course materials for a more comprehensive understanding.