Hi

I am zahra rashedi. I am student on my maser projects in sharif universityy of technology.In my project, I must be obtained optimal condition for sterilization of baby powder with Ethylene oxide. There are two problems. When baby powder was sterilizated with EtO, some of residue such as Ethylene oxide, Ethylene glycol, Ethylene chloro hydrin remained on my product. One of the most important of problems is measurement of these residues. Other problem is that I can not measure set pressure and gas concentration. Do you think, I must be changed my method for sterilization, or not. Please help me as soon as possible. I will wait for your answer.
Best Regards.

Hello Zahra!

It's great to hear about your project on sterilization of baby powder with Ethylene oxide. It seems like you have encountered two problems, the first being the presence of residue such as Ethylene oxide, Ethylene glycol, and Ethylene chloro hydrin on your product, and the second being the inability to measure the set pressure and gas concentration.

To address the first problem, measuring the residues on your product can be done through analytical techniques such as gas chromatography or mass spectrometry. These methods can determine the presence and concentration of specific compounds like Ethylene oxide, Ethylene glycol, and Ethylene chloro hydrin. By performing these analyses, you can assess the effectiveness of your sterilization process and determine whether changes need to be made.

Regarding the second problem, not being able to measure set pressure and gas concentration can limit your ability to control and optimize the sterilization process. It is crucial to have accurate measurements of these parameters to ensure proper sterilization. There are several ways to measure pressure, such as using pressure sensors or gauges that can provide real-time monitoring. Similarly, gas concentration can be measured using gas analyzers or chemical sensors.

Considering the importance of accurate pressure and gas concentration measurements in achieving optimal sterilization conditions, it may be necessary to find a way to address this issue. This could involve either finding suitable measurement instruments or adapting your sterilization method to allow for measurement.

In conclusion, it is essential to assess the residues on your product through analytical techniques and find a way to measure set pressure and gas concentration to ensure optimal sterilization conditions. If these challenges cannot be adequately addressed with your current method, you may need to consider alternative sterilization methods. However, further evaluation is needed based on the specific requirements of your project and the available resources.

I hope this helps you in your project! If you have any further questions, feel free to ask. Good luck with your research!

Best regards,
Step-by-Step Bot

Hello Zahra,

It seems like you are facing a couple of problems in your project related to the sterilization of baby powder with Ethylene oxide. Let's discuss each issue separately.

1. Residue Measurement: To measure the residue left on your product after sterilization, you need to follow appropriate analytical methods. There are several techniques you can use:

a. Gas Chromatography (GC): GC can be used to analyze volatile organic compounds such as Ethylene oxide. You would need to extract the residue from the baby powder, prepare a sample, and then analyze it using GC equipped with detectors suitable for volatile compounds.

b. High-Performance Liquid Chromatography (HPLC): HPLC can be used to measure less volatile compounds such as Ethylene glycol and Ethylene chlorohydrin. Similarly, you would need to extract the residue, prepare a sample, and analyze it using HPLC with suitable detectors.

These techniques require specialized equipment and expertise. It would be advisable to consult with an analytical chemist or a laboratory that specializes in residue analysis to help you with the methodology and interpretation of the results.

2. Measurement of Set Pressure and Gas Concentration: To accurately measure the set pressure and gas concentration during the sterilization process, you may need to consider the following steps:

a. Calibration: Ensure your instruments are properly calibrated. Calibrate any pressure gauges or sensors and gas concentration analyzers to ensure accurate measurements. Follow the manufacturer's instructions for calibration procedures.

b. Sampling: Place the appropriate sensors or probes in the sterilization chamber to monitor pressure and gas concentration. It's important to place them in representative locations to get the most accurate measurements.

c. Data Logging: Use suitable data logging equipment to record the pressure and gas concentration measurements over the duration of the sterilization process. This will help you track any fluctuations or variations.

If you are having trouble measuring set pressure and gas concentration, you may want to consult with an instrumentation expert or reach out to the manufacturer of your sterilization equipment for guidance.

Considering whether you should change your sterilization method or not depends on various factors such as the effectiveness of Ethylene oxide sterilization on baby powder, the feasibility of resolving the residue measurement issue, and the availability of alternative sterilization methods. It would be beneficial to consult with your advisor, experts in the field, or relevant literature to make an informed decision.

I hope these suggestions help you in resolving the problems you are facing. Good luck with your project!