can any one tell me how the distance between the oxygen atom joined to the ring and the -OH group of the carboxylic acid in aspirin ... can relieve pain?

Question

can any one tell me how the distance between the oxygen atom joined to the ring and the -OH group of the carboxylic acid in aspirin ... can relieve pain?

For example what would be the effect of increasing the distance ?

Here is a LONG discussion of aspirin, much of it unrelated to your question. However, if you will scroll to the section on "mechanism of action" there is a discussion that may be of benefit to you. http://en.wikipedia.org/wiki/Aspirin

Here is a LONG discussion of aspirin, much of it unrelated to your question. However, if you will scroll to the section on "mechanism of action" there is a discussion that may be of benefit to you.

Answer 1

The relief of pain caused by aspirin is not directly related to the distance between the oxygen atom joined to the ring and the -OH group of the carboxylic acid. The mechanism of action of aspirin is more complex and involves its ability to inhibit the production of prostaglandins, which are chemical messengers that contribute to inflammation, fever, and pain.

Aspirin belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the enzyme cyclooxygenase (COX), which plays a key role in the production of prostaglandins. By blocking the production of prostaglandins, aspirin helps to reduce inflammation and relieve pain.

Increasing the distance between the oxygen atom and the -OH group in aspirin may not have a direct effect on its pain-relieving properties. The efficacy of aspirin as a pain reliever is mainly determined by its ability to inhibit COX and decrease prostaglandin production.

However, it is worth noting that altering the structure of aspirin or modifying its chemical properties can have implications for its overall pharmacokinetics, including its absorption, distribution, metabolism, and excretion in the body. These factors can affect the drug's efficacy and safety profile.

It is always important to consult with a healthcare professional or refer to reliable sources such as scientific studies or reputable pharmaceutical information to get accurate and up-to-date information about specific medications and their mechanisms of action.