If there was a reaction between organic compounds: OH + Cl --> O + HCl,

how would I determine which atoms is the nucleophile (O, Cl, or H)?

Here is a picture of the reaction:

img33.imageshack.us/img33/3923/29529709.jpg

From my understanding, a nucleophile is an electron donor. But I'm not really sure about this question.
Thanks.

I believe the nucleophile is the alcohol (more specifically, the O of the alcohol). See here.

http://www.organic-chemistry.org/namedreactions/nucleophilic-substitution-sn1-sn2.shtm

Thank you! Especially for the source, it has helped my understanding for SN1 and SN2 mechanisms.

To determine the nucleophile in a reaction, you need to identify the atom that donates a pair of electrons in the reaction. In this case, the reaction involves the compounds OH and Cl, leading to the formation of products O and HCl.

To determine the nucleophile, you will need to look at the electron configuration and electronegativity of the atoms involved. The atom more likely to donate a pair of electrons will act as the nucleophile.

In this reaction, both OH and Cl can potentially act as nucleophiles since they both have lone pairs of electrons. However, to determine which one is the more reactive nucleophile, you need to consider the electronegativity and chemical characteristics of the atoms.

Chlorine (Cl) is more electronegative than oxygen (O), which means it has a stronger pull on electrons. This makes oxygen more likely to donate its lone pair of electrons.

Therefore, in this reaction, O is most likely the nucleophile, while Cl would be the electrophile (electron acceptor). The H atom is not involved in any electron donation or acceptance in this specific reaction and does not act as a nucleophile.

It's important to note that the determination of the nucleophile in a specific reaction may vary depending on the specific circumstances and reaction conditions. Therefore, it is always good to consider these factors when analyzing the chemical behavior of organic compounds.