1. His face looked familiar to me.
2. I looked familiar with his face.
(Are both the same?)
3. The subject is familiar to me.
4. I am familiar with the subject.
(Are both the same?)
Number 1 is right, but 2 is wrong. They are not the same.
Both 3 and 4 are right, and they are the same -- although # 4 is used more often.