16 1/4 simplify expression assume all variables represent positive numbers

I see no variables.

16 1/4 is about as simple as it gets, unless you just want a fraction or decimal:

65/4 or 16.25

I suspect you left something out...

To simplify the expression 16 1/4, you need to convert the mixed number (16 1/4) into an improper fraction. Here's how you can do it:

Step 1: Multiply the whole number (16) by the denominator of the fraction (4) and add the numerator (1).
16 x 4 + 1 = 64 + 1 = 65

So, 16 1/4 can be written as the improper fraction: 65/4.

Now, to simplify this fraction, you can find the greatest common divisor (GCD) of the numerator (65) and the denominator (4). In this case, the GCD is 1, which means the fraction is already in its simplified form.

Therefore, the simplified expression for 16 1/4 is 65/4.