What are two situations in which mechanism can be detrimental

You have to define what type of mechanisms you mean: biochemical, physical, etc.
It is dangerous to stand in front of an automobile while it is running...

sorry if I did not make myself clear!
the question before that one went as follows:
Identify and briefly describe one body mechanism for fighting invasion by a foreign protein.

My answer:We were given T cells to fight of foreign invasions. The killer T cells secrete proteins that punch holes in the infected cell's plasma membrane.

then it says:
b. Describe two situations in which this mechanism can be detrimental

I still don't know???

There are situations in which the autoimmune system attacks the body, as with arthritis and lupus. Search the Internet for more information on these two disorders.

I hope this helps. Thanks for asking.

In cancer, and some other diseases, T cells regulate the immune system in a counter productive way: The T cells will inhibit the immune response, allowing the cancer cells free reign.
In the case of AIDS, the virius causes a massive amount of T cells to be formed, and then the "superantigen" prevents them from being cloned, thus, the information stored on the variable portion of the t cell is not reproduced, and the person becomes then very likely to suffer from a another disease that is usually stopped dead in its tracks by the immune system.

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In the context of the body's immune system and the mechanism of T cells fighting invasion by foreign proteins, there are two situations in which this mechanism can be detrimental.

1. In some diseases, such as cancer, T cells can regulate the immune system in a counterproductive way. Instead of attacking the cancer cells, the T cells inhibit the immune response, allowing the cancer cells to continue growing and spreading.

2. In the case of AIDS (Acquired Immunodeficiency Syndrome), the HIV virus causes a massive amount of T cells to be formed. However, a "superantigen" prevents these T cells from being cloned, resulting in a decreased number of functional T cells. This weakens the immune system and makes the person more susceptible to other diseases that are normally controlled by the immune system.

To learn more about these two situations, you can search the internet using relevant keywords like "T cells and cancer" or "T cells and AIDS." This will provide you with more details and information on how these mechanisms can be detrimental in these contexts.