Dr Bob 222

You answered a earlier post on a question for someone with the same question I am trying to answer.
The hydrolysis of tocainide
you stated only the NH2 group hydrolyses NH2 + HOH -> NH3^+ OH^-

I understand that part but I need to understand why the amimine only hydrolyses. Am I to understand that the amide part is unchanged and if so why?

I will try and recreate the structural formulae as best I can

Benzene ring with 2 CH3 attached. One N attached to ring. N has a C attached and one H to it. The C attached to the N is attached to a CH which in turn has a CH3 and a NH2 attached to it.
So, there is a amide and a amine here.
I don't understand enough about hydroysis yet. I can work it out OK with one functional group but have trouble when there is more than one. If the amide hydroysed then I would get a acid and a alcohol. Somewhere along the line I have missed something don't like answering anything without understanding it properly. I would be very grateful for your help me once before and put it over clearer than my tutor.

It's tough to draw structures, or even describe them, on the computer. I looked up the structure of tocainide in my home copy of The Merck Index.

Amines are basic and, by the Bronsted-Lowry theory, accept protons from water. Reaction with water is hydrolysis. Amines usually are basic enough that they require nothing more than addition of water to react. Amides are neutral. The -CONH2 (amide) group CAN be hyrolyzed but it is tougher to do so. Under (usually) high acidic conditions (such as strong HCl), the -CONH2 group forms NH3 + the corresponding RCOOH acid and those two react to form the ammonium salt (RCOO^- + NH4^+). Under (usually) high basic conditions (such as NaOH or KOH), the RCOO^- + NH4^+ salt is formed directly without going through the intermediate steps. The way I understood the problem, it was a simple hydrolysis withough strong acid or alkali present. I hope this helps.

Thank you very much for taking the time to help me

  1. 👍
  2. 👎
  3. 👁

Respond to this Question

First Name

Your Response

Similar Questions

  1. Math HELPPP

    In a survey of 2000 adults 50 years and older of whom 40% were retired and 60% were pre-retired, the following question was asked: Do you expect your income needs to vary from year to year in retirement? Of those who were retired,

  2. Math

    the 64 people who answered "yes" to a question, 6 were male. Of the 70 people that answered "no" to the question, 8 were male. If one person is selected at random from the group, what is the probability that the person answered

  3. math

    A teacher prepares a test. She gives 5 objective type questions out of which 4 have to be answered. Find the total ways in which they can be answered if the first 2 question have 3 chioce and the last 3 have 4 choices. I think

  4. Why can't I post

    I don't know why, but i am getting a friend to post this up for me, but i cannot post a question, when i do, the successful window never comes up. it just goes back to the forum and doesnt add. can anyone help me why? or what i

  1. Geometry

    I HAVE A QUESTION. When I post a question and there is now response to it does it means that my answer to my questions are correct? I post two questions yeaterday and received no response .Today I post the same two questions and

  2. General

    How come when someone asks a question others cant look at their question... all i see is the name of the person the subject and teacher of that subject!:( I tried to click on it to see the question and poof!!!! NOTHING btw wheres

  3. HHS 235

    Discussion Question 1 • Due Date: Day 2 [Main] forum • Post your response to this question: Answer Question 3 on p. 150 (Ch. 6) in Ethical Leadership in Human Services regarding the ethical dilemma of a reduction in force

  4. "It Happened To Nancy'

    How do you feel about what happened to Nancy? *My homework is to create a table showing what people felt about what Happene to nancy. Thank you for using the Jiskha Homework Help Forum. I answered this earlier but I see it didn't

  1. science

    The speed of light in a prticular ype of glass is 1.68x10^8 m/s. What is the index of refraction of the glass? I don't understand if how to solve this problem. Do you put an index of refraction of glass that you know or are you

  2. For George

    At 11:37 and at 12:24 you posted the same question the earlier one was answered correctly by drwls by accepting your question the way you typed it. my solution is based on the assumption that your denominator was e^(t-7), an

  3. Science

    What is the average summer temperature in the desert biome? Select one: a. 38 degrees celcius b. 48 degrees celcius c. 58 degrees celcius Question 2 Not yet answered Marked out of 1.00 Flag question Question text What is the

  4. English

    Can you please answer my question? I posted the question before.But nobody gave an answer. It is middle of the Jiskha Homework Help Forum page. Where it says: NAME:KHUSHI SUBJECT:INTERESTING FACT AND CHRISTMAS JUST CLICK ON IT,

You can view more similar questions or ask a new question.