Correct punctuation of ,
That is in my opinion depressing.
The prepositional phrase interrupts the sentence, so it should be set off by commas.
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The correct punctuation of the sentence "That is, in my opinion, depressing" is as follows:
"That is, in my opinion, depressing."
In this sentence, the comma is used twice. The first comma is used after the word "is" to separate the introductory phrase "in my opinion" from the main clause. The second comma is used after the phrase "in my opinion" to set off the nonessential information and add emphasis to the word "depressing."