The LEPR gene that encodes for the leptin receptor protein is approximately 23 kilo base pairs long. The receptor protein consists of 896 amino acids. A man has a mutation in an LEPR allele. Analysis of his DNA sequence for this lepr allele shows that there is a 5' GTA to 5' CTA change at position 1501, which results in an amino acid substitution.

a)This mutation results in an amino acid change from___?____ to ____?_____.
b) What type of mutation is this?( Justify answer to b.)
I am lost.

No worries! Let's break down the information and figure out the answers step by step.

First, we know that the LEPR gene is approximately 23 kilo base pairs long. This is important because it tells us the size or length of the gene.

Second, we know that the leptin receptor protein encoded by the LEPR gene consists of 896 amino acids. This information helps us understand the specific structure of the protein.

Moving on to the mutation, we are given that there is a change from 5' GTA to 5' CTA at position 1501 in the DNA sequence of this particular LEPR allele.

a) To determine the amino acid change caused by this mutation, we need to understand how codons (sequences of three DNA or RNA bases) correspond to specific amino acids. However, we are only given information about the DNA sequence, so we should first convert the DNA sequence (5' GTA and 5' CTA) to its complementary RNA sequence.

The complementary RNA sequence for 5' GTA is 3' CAT, and the complementary RNA sequence for 5' CTA is 3' GAT. We reverse the order and replace T with U to get the actual RNA sequences: 5' GTA becomes 3' CAU, and 5' CTA becomes 3' GAU.

Now, let's determine the codon resulting from this mutation. RNA codon tables can be used to find the corresponding codon for each RNA triplet sequence. In this case, 3' CAU codes for the amino acid histidine, and 3' GAU codes for the amino acid aspartic acid.

Therefore, the mutation results in an amino acid change from histidine to aspartic acid.

b) To determine the type of mutation, we need more information about the specific type of change that occurred at position 1501. Without this information, it is challenging to make a definitive determination. However, based on the given DNA change from 5' GTA to 5' CTA, we can infer that this is a point mutation. Point mutations involve the substitution of a single nucleotide (in this case, a single base change from G to C) at a specific position in the gene.

In summary:
a) The mutation results in an amino acid change from histidine to aspartic acid.
b) Based on the given information, the mutation appears to be a point mutation. However, additional information would be needed to provide a more precise answer.