simplify expression (no negative exponents)

-2^-3(xy^3)^-2/x^-1y^-3

I got 1/-8x^2y^2

-2^-3(xy^3)^-2 = -1/(8x^2y^6)

x^-1y^-3 = 1/(xy^3)

now divide (multiply by the reciprocal) and you have

-1/(8x^2y^6) * xy^3 = -1/(xy^3)

or, you can just do it like this

-2^-3 (xy^3)^-2 (xy^3)
= 1/8 (xy^3)^-1
= -1/(8xy^3)