8^(-4/3) + 2^(-2) OVER 16^(-3/4) + 2^(-1)

8^(-4/3) = [2^3]^(-4/3) = 2^-4 = 1/16

2^-2/[2^4]^(-3/4) = 2^-2/2^-3 = 2
2^(-1) = 1/2

Now add them up.