When treating a patients physicians use an isotonic means that this solution will have the same osmotic pressure as the body fluid

such as blood. how many grams of glucose (C6H12O6) is in 100.0 g of H2O in the isotonic glucose solution (5.00% m/m)?

I don't think this is exactly an isotonic solution but the answer to your question is that a 5.00 (mass/mass) solution of glucose contains 5.00 g glucose/100 g solution.

Note:
I don't know the density and it may be that the density of the solution may correct it to be isotonic with blood.

To find the amount of glucose in the isotonic glucose solution, you need to determine the mass of glucose in 100.0 g of water.

The given concentration of the solution is 5.00% m/m, which means that 5.00 grams of glucose are present in every 100.0 grams of the solution.

To calculate the mass of glucose in 100.0 g of water, you can use the following steps:

Step 1: Determine the mass of the glucose solution in 100.0 g of water.
Mass of solution = Mass of water + Mass of glucose
Mass of solution = 100.0 g (given)

Step 2: Calculate the mass of glucose in the solution.
Mass of glucose = Concentration of glucose × Mass of solution
Mass of glucose = (5.00% m/m) × (100.0 g)

Step 3: Convert the percentage to a decimal by dividing it by 100.
Mass of glucose = (5.00 / 100) × (100.0 g)

Step 4: Calculate the mass of glucose in grams.
Mass of glucose = 5.00 g

Therefore, there are 5.00 grams of glucose (C6H12O6) in 100.0 g of water in the isotonic glucose solution.