What percentage of the F2 offspring predicted in a cross for mice coat color
In mice, the allele for black fur is dominant to the allele for brown fur. If a male homozygous black mouse is crossed with a female brown mouse, what percentage of the F2 offspring do you predict will be homozygous?
Since both parents have to be homozygous, all of F1 will be heterozygous (Bb).
Do a Punnett square for F2.
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50
25
To predict the percentage of homozygous offspring in the F2 generation, we need to understand the principles of Mendelian genetics. In this case, we know that the allele for black fur is dominant (B) to the allele for brown fur (b).
When a homozygous black mouse (BB) is crossed with a homozygous brown mouse (bb), their F1 offspring will all be heterozygous (Bb) because they inherit one allele from each parent.
Then, when the F1 generation is crossed with each other (Bb x Bb), there is a 25% chance of obtaining homozygous dominant black (BB), a 25% chance of obtaining homozygous recessive brown (bb), and a 50% chance of obtaining heterozygous black (Bb) offspring.
Since we are interested in the percentage of homozygous offspring in the F2 generation, we combine the percentages for BB and bb, which gives us a 25% chance of obtaining homozygous offspring in the F2 generation.