Hello,
Can someone explain to me the Pharmacokinetics of
1. Ibuprofen
2. PREDNISONE
I am looking through my textbook but there is absolutely no information on it.
http://www.google.com/#q=Pharmacokinetics+of+++1.+Ibuprofen+
Thank you Ms sue.
I tried online but I found them very confusing. The websites don't really state the processes (absorption, distribution, excretion) of the drugs in the body.
Of course! I can help explain the pharmacokinetics of Ibuprofen and Prednisone.
1. Ibuprofen:
To understand the pharmacokinetics of Ibuprofen, we consider its absorption, distribution, metabolism, and elimination in the body.
- Absorption: Ibuprofen is rapidly absorbed from the gastrointestinal tract after oral administration. It is mostly absorbed in the stomach and upper small intestine.
- Distribution: Ibuprofen is highly protein-bound, primarily to albumin. It has a relatively small volume of distribution, meaning it stays mainly within the blood plasma. It can cross the blood-brain barrier, allowing it to have both peripheral and central effects.
- Metabolism: Ibuprofen undergoes extensive metabolism in the liver. It is primarily metabolized by cytochrome P450 enzymes, specifically CYP2C9. The main metabolites include inactive carboxylic acids and glucuronide conjugates.
- Elimination: The elimination half-life of Ibuprofen is approximately 2 to 4 hours in adults. It is primarily eliminated through the kidneys, with about 90% of the dose excreted as metabolites in the urine. The remaining fraction is eliminated in the feces.
2. Prednisone:
Let's discuss the pharmacokinetics of Prednisone as well.
- Absorption: Prednisone is rapidly absorbed from the gastrointestinal tract after oral administration. It undergoes extensive first-pass metabolism in the liver, where it is converted to its active form, prednisolone.
- Distribution: Prednisone and its active metabolite prednisolone have a significant volume of distribution. They bind to plasma proteins, mainly albumin and transcortin. These drugs can cross cell membranes and distribute into various tissues.
- Metabolism: Prednisone is primarily metabolized in the liver by enzymes belonging to the CYP3A subfamily. It undergoes several enzymatic conversions, including hydroxylation and conjugation, to produce the active metabolite prednisolone.
- Elimination: The elimination half-life of prednisone is about 2 to 4 hours. It is primarily eliminated through the kidneys, mainly as metabolites. Some prednisolone is also excreted in bile and undergoes enterohepatic recirculation.
In both cases, it's important to note that individual variations in pharmacokinetics may occur due to factors such as genetics, age, and specific patient characteristics. It's always good to consult the prescribing information or seek advice from a healthcare professional for specific details or concerns.
If you don't find enough information in your textbook, you can explore other reliable sources such as medical literature, pharmacology textbooks, or professional databases like PubMed, for a more comprehensive understanding of the pharmacokinetics of Ibuprofen and Prednisone.