what happens to insulin when kidney failure happens?
The half life of insulin is prolonged due to less degradation.
http://clinical.diabetesjournals.org/content/25/3/90.full
Thank you
When kidney failure occurs, it can have an impact on the processing and elimination of insulin. The kidneys play a crucial role in removing waste from the bloodstream, including insulin. Insulin, a hormone produced by the pancreas, helps regulate blood sugar levels.
In cases of kidney failure, the kidneys may become less efficient in filtering and excreting insulin, leading to a buildup of insulin in the body. This can cause a condition called insulin resistance, where the body's cells become less responsive to the effects of insulin. As a result, blood sugar levels may become difficult to control, leading to hyperglycemia (high blood sugar).
When kidney function declines further, it can eventually lead to end-stage renal disease (ESRD), where the kidneys are no longer able to perform their functions adequately. At this stage, patients may require renal replacement therapy, such as dialysis or a kidney transplant, to filter waste products, including insulin, from the blood.
It is important for individuals with kidney failure to work closely with their healthcare team, including endocrinologists and nephrologists, to manage their blood sugar levels and adjust their insulin dosages accordingly. Monitoring blood sugar levels regularly and making dietary and lifestyle modifications are also essential components of diabetes management in the presence of kidney failure.