Consider the pedigree below. This pedigree represents a family with a rare genetic disease.

Note two very important assumptions:

Individuals who marry into the family may carry a disease allele.
The disease is completelely penetrant. That is, any individual with a genotype corresponding to a disease phenotype will show the disease.

(a) Is this pedigree consistent with autosomal recessive inheritance?

Yes
No
If you chose "yes", answer questions (i) and (ii) and leave parts (iii) and (iv) blank. If you chose "no", leave parts (i) and (ii) blank and answer questions (iii) and (iv).

i) If you chose "yes" above. Drag and drop in the appropriate genotype from the options below to indicate the genotypes of all the individuals in the pedigree. You may use each of the labels below once, more than once, or not at all. Note that the upper case letter indicates the allele with the dominant phenotype.

A_AaaaAA
unanswered
ii) If you chose "yes" above. If Individuals 5 and 6 have another child, what is the probability that the child will be affected by the disease? Please give a number between 0.0 and 1.0. Use as many significant digits as you need.

unanswered
iii) If you chose "no" above. Which set or sets of individuals is inconsistent with autosomal recessive inheritance? Choose all that apply from the list below:

Individuals 1, 2, 3, and 5
Individuals 3, 4, 7, and 8
Individuals 5, 6, 9, and 10
Individuals 10, 11, 12, and 13
iv) If you chose "no" above. Can you change one individual from affected to unaffected and make this pedigree consistent with autosomal recessive inheritance? If so, give the number of that individual. If it is not possible, enter 0.

Typically "carrying an allele" means that, although it is in the genotype, is is not evident in the phenotype. Thus only aa individuals would have the disease.

However, we do not have any data that allows us to identify individuals by number.

No.iii) If you chose "no" above. Which set or sets of individuals is inconsistent with autosomal recessive inheritance? Individuals 10, 11, 12, and 13

iv) If you chose "no" above. Can you change one individual from affected to unaffected and make this pedigree consistent with autosomal recessive inheritance? If so, give the number of that individual
11.

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To determine whether this pedigree is consistent with autosomal recessive inheritance, we need to analyze the pattern of disease inheritance and the genotypes of the individuals in the pedigree.

(a) To answer whether this pedigree is consistent with autosomal recessive inheritance, we will first analyze the pattern of disease inheritance. Autosomal recessive inheritance means that individuals with the disease must inherit two copies of the disease allele (one from each parent) to be affected. Let's analyze the pedigree to see if this is the case.

(i) If the answer to (a) is "yes", we need to determine the genotypes of all the individuals in the pedigree. We need to drag and drop the appropriate genotype from the options provided.

(ii) If Individuals 5 and 6 have another child, we need to determine the probability that the child will be affected by the disease. This can be calculated by considering the genotypes of Individuals 5 and 6 and using the principles of autosomal recessive inheritance.

(iii) If the answer to (a) is "no", we need to identify which set of individuals is inconsistent with autosomal recessive inheritance. We need to choose all the sets of individuals that do not follow the pattern of autosomal recessive inheritance.

(iv) If the answer to (a) is "no", we need to determine if it is possible to change one individual from affected to unaffected to make the pedigree consistent with autosomal recessive inheritance. If it is possible, we need to provide the number of that individual. If it is not possible, we need to enter 0.

Please let me know which option you would like to explore further, and I'll guide you through the process.