Evaluate Integral x^2+4 / x^4+x^2+16 dx

gotta get creative with this one. Note that

x^4+x^2+16 = x^4-8x^2+16 - 9x^2 = (x^2-4)^2 - (3x)^2

= (x^2-4)^2 [(3x/(x^2-4)^2)^2 + 1]

so, if you let u = 3x/(x^2-4)
du = -3(x^2+4)/(x^2-4)^2 and you have

integral -1/3 du/(1+u^2)

take it from there!