Which cities are the major trading centers for each of the major continents, and what led to their development?

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The major trading centers are those that are easily accessible by ship. Most of them are on an ocean -- or short distances from an ocean via a navigable river. An exception is Detroit, Chicago, and Duluth and others which are on the Great Lakes.

To determine the major trading centers for each major continent and the factors that led to their development, we can analyze historical, geographical, and economic factors. Let's break it down continent by continent:

1. Europe:
- London, United Kingdom: London became a major trading center due to its strategic position along the River Thames, which provided access to the Atlantic Ocean. It played a crucial role in maritime trade during the British Empire era and continues to be a significant financial hub.
- Rotterdam, Netherlands: Rotterdam is Europe's largest seaport and a major trading center due to its central location in Western Europe and its connection to the Rhine-Main-Danube corridor, which links the North Sea to the Black Sea.
- Hamburg, Germany: Located on the Elbe River, Hamburg has been an important trading port for centuries, enabling access to the Baltic Sea and facilitating trade with Scandinavia and Eastern Europe.

2. Asia:
- Shanghai, China: As China's largest city and a major financial center, Shanghai has become a prominent trading hub due to its location on the Yangtze River and the East China Sea. It acts as a gateway for imports and exports in manufacturing and transportation.
- Tokyo, Japan: Tokyo is a major trading center and financial hub due to its central role in the Japanese economy. Its location on the Pacific Ocean and its advanced infrastructure contribute to its trading prominence.
- Mumbai, India: Mumbai has emerged as a major trading center due to its strategic location on the Arabian Sea, making it a key port for trade with the Middle East and Africa. It also serves as India's financial capital.

3. North America:
- New York City, United States: New York City's development as a major trading center was primarily driven by its geography, being situated on the natural harbor of the Hudson River, which connects to the Atlantic Ocean. It has a prominent role in global finance and international trade.
- Los Angeles, United States: Located on the West Coast, Los Angeles is a significant trading center due to its port infrastructure, which handles a large volume of trade with Asia and Latin America.
- Toronto, Canada: Toronto's position as Canada's largest city and financial center contributes to its role as a major trading hub. It benefits from its proximity to the Great Lakes and its extensive transportation network.

4. South America:
- Sao Paulo, Brazil: Sao Paulo has become a major trading center due to its large population, industrial base, and economic importance. It acts as the financial hub of Brazil, which is South America's largest economy.
- Buenos Aires, Argentina: Buenos Aires plays a vital role in South American trade due to its location along the mouth of the Rio de la Plata, making it a natural gateway for Argentina's exports and imports.
- Santiago, Chile: Santiago acts as a trading center in South America due to its position as Chile's capital city and its central location within the country. It serves as a hub for various industries, including mining and agriculture.

It's important to note that the development of these major trading centers is influenced by historical factors, geographical advantages, transportation infrastructure, political stability, and economic policies, among other factors.