Are these sentence's punctuated correctly?

The new heart clinic is located at 555 NW First Street, Seattle Washington 98104.

Transcription should be interesting, educational, always challenging, and, most of all, fun.

Additionally, anesthesia was given by intercostal nerve blocks, with 0.25% Marcaine, with epinephrine, as well as local infiltration with 0.50% Xylocaine with epinephrine.

Comma after Seattle.

No comma after Marcaine.