biology

posted by .

Can someone explain to me how 2,3 BPG works for hemoglobin?

BPG affects oxygen binding affinity by binding in a small cavity at the center axis of deoxygenated hemoglobin. In oxygenated hemoglobin, this cavity is too small to effectively accommodate 2,3-BPG. When bound, 2,3-BPG stabilizes the deoxygenated conformation of hemoglobin, greatly diminishing the binding of oxygen and facilitating oxygen unloading to actively respiring tissues.

How can oxygen be unloaded if the cavity is too small for 2,3 BPG to enter in the first place?
Or is this possible only when the hemoglobin is not fully oxygenated?

Respond to this Question

First Name
School Subject
Your Answer

Similar Questions

  1. BIOLOGY

    True of false: 1. The Bohr effect explains the manner in which pH changes the binding affinity of hemoglobin for O2. i think this is true 2. Hemoglobin binding affinity increases as Po2 increases. im not sure about this 3. O2 will …
  2. Chemistry

    Chemical analysis show that hemoglobin contains 0.34 percent Fe by mass. What is the minimum possible molar mass of hemoglobin?
  3. Chemistry

    a) An equilibrium exists between three chemical species in the blood , Hemoglobin, oxygenated hemoglobin and oxygen. Using the symbols Hb for hemoglobin , O2 for oxygen and HbO2 for oxygenated hemoglobin write out the equilibrium reaction. …
  4. Chemistry

    Hemoglobin, an oxygen-carrying protein in blood, contains 4 iron atoms per molecule and the iron comprises 0.34% of the molecules mass. What is the molecular weight of hemoglobin?
  5. statistics

    The average hemoglobin reading for a sample of 20 nurses was 16 grams per 100 mL, with a sample standard deviation of 2 g. Assume the hemoglobin readings are approximately normally distributed. The 98% confidence interval for the true …
  6. chemistry

    A solution was made by dissolving 5.15 mg of hemoglobin in water to give final volume of 1.00 mL. The osmotic pressure of this solution was 1.97 x 10^-3 atm at 25C. Calculate the molar mass of hemoglobin. pi = iMRT i = 1 since hemoglobin …
  7. chemistry

    hemoglobin is the protein that transports O2 through the blood from the lungs to the rest of the body. in doing so, each molecule of hemoglobin combines with four molecules of O2. if 1.00 g of hemoglobin combines with 1.53 mL of O2 …
  8. chemisrt

    The hemoglobin content of blood is about 15.4g/100mL blood. The molar mass of hemoglobin is about 64500 g/mol, and there are four iron (Fe) atoms in a hemoglobin molecule.Approximately how many Fe atoms are present in the 6 L of blood …
  9. chemistry

    Hemoglobin is the oxygen carrying molecule of red bloods and contains 4 atoms of iron per molecule of hemoglobin. A sample of hemoglobin weighing 13.4 g contains 45.6 mg iron. What is the molecular mass of hemoglobin?
  10. Chemistry

    Please someone explain the best way of solving this. A 55 kg woman has 7.5 x 10 to the power of negative 3 moles of hemoglobin (Molar mass=64,456 g/mole) in her blood, how many hemoglobin molecules is that?

More Similar Questions