243^(.2x)= 81^(x+5)

both 243 and 81 are powers of 3

243 = 3^5 and 81 = 3^4

so rewrite your equation:

243^(.2x)= 81^(x+5)
(3^5)^(.2x) = (3^4)^(x+5)
3^x = 3^(4z+20)

If the bases are the same, for the equation to be true, obviously the exponents have to be the sam

so x = 4x+20
x = -20/3