How do you calculate 1 mole of CuSO4 × 5 H2O?

Its mass will be 63.5 + 32 + 4*16 + 5*18 grams. Add them up. That is the total of the atmomic mass numbers for all atoms in the hydrated molecule. The 5*18 accounts for the five water molecules. I used 32 for S (sulfur) and 63.5 for copper, 1 for H and 16 for O.